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Abstract (ENG) The object of my work, which I’ll describe in the following pages, is an innovating technology with the purpose of automatizing prescriptions, distributions and management of drugs in hospitals, called Mario® (developed by Ingegneria Biomedica Santa Lucia S.p.a.). The first goal is the decision of a pool of parameters which allow performance evaluation for each system and the comparison among the three different versions which I observed and analyzed. Once parameters have been chosen, it’s necessary to define protocols for their evaluation or esteem. Those protocols will include the execution of experimental tests in loco and the analysis of Mario®’s database to assess their past performance. The tests results will be then exposed with particular emphasis on the differences caused by hardware upgrades from the oldest version to the newest ones, or by eventual anomalies. An optimal value for each parameter will then be set. The next step consists in investigating the reason of performance gaps occurring between the three Mario®s, and the elaboration and actuation of improvement protocols for the ones with the poorest results. Finally, tests will be repeated to assess the impact of the modifications, by comparing the before/after parameter values, and this will come with suggestions about the use of the system in order to avoid critical situations and anomalies. Everything will be introduced by two chapters describing what was the drugs iter from the pharmacy to the patient’s bed before automatization and informatization, with emphasis put on the critical factors which led to the introduction of those systems. This will be followed by a brief description of the main technologies used in Italy nowadays, among which figures Mario®. 4