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___________________________________ Line-Quotation ___________________________________ Uhlmann Pac-Systeme GmbH & Co. KG, Uhlmannstr. 14-18, 88471 Laupheim Customer-Number: 4200002 AstraZeneca Sweden Operations Drug Products Supply Gärtuna Godsmottagningen Byggn 621 SE-151 85 SÖDERTÄLJE SCHWEDEN Page Date 1 of 25 07.07.2010 Project-No. 999102144 Your Enquiry E-Mail Astra Zeneca dated 21.05.2010 Your Contact Person Roger Asplund Our Contact Phone No. Fax No. E-mail nordiska.se Joachim Gerike +46 (031) 450 506 +46 (031) 452 505 joachim.gerike@uhlmann- ___________________________________ Bill-to-Party: 4200014 AstraZeneca AB DPS / Accounts Payable SE-389 80 ÖSTERSUND SCHWEDEN Line Quotation consisting of 500120809 ZA5 Uhlmann Blister Machine UPS 5 ET - Version: 2 500125101 ZA5 Validation and Services - Version: 1 Uhlmann Blister Machine UPS 5 ET We would like to thank you for your inquiry. Based on our conditions of sales and supply we quote as follows: ____________________________________________________________________________________ Pos. Product Name/ Products per BlisterBlister per Dimensions mm blister format mm forming stroke ____________________________________________________________________________________ 1a Polybag 125 ml 86x18x230 1 267 x 115 x 39 1x2 1b Polybag 250ml 86 x 34 x 236,2 1 267 x 115 x 39 1x2 Line-Quotation 500120809 1c Polybag Japanese design 86x19x219,6 1 Page 2 of 25 Date 07.07.2010 267 x 115 x 39 1x2 __________________________________________________________________________________ Pos. Reel width mm Index Drawing Output Forming / Sealing length mm No. blister/min. ____________________________________________________________________________________ 1a-1c 272 / 256 272 Forming material: PP 600 µm Lidding material: Paper 60g/m Line layout according to floor plan no.11420165-01 79 006 710 40 Line-Quotation 500120809 Page 3 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ 1500 1 EA 81010958 UHLMANN Blister Machine UPS 5 for PVC and PET forming film and aluminium lid foil Basic machine in cantilevered and modular design, with 12 modules on torsion-free frame: - Forming material support with 2 pneumatically operated shaft spreaders for core diameter of 76 mm, max. reel diameter 800 mm - Cutting and splicing table for forming film - Forming material unwind, continuous motion - Contact heating with 3 heating zones: - 6 heating circuits, individually controlled and adjustable - simultaneous heating of min. 3 index lengths - automatic opening of heating plates during machine stop - rapid changeover - Forming station with tension rod, tools to be removed to operator side - Clamping gripper for fixing of web during machine dwell time - Fill section with safety flap, length 1.360 mm - Unwind for lid material at operator side with pneumatically operated shaft spreader for reel core diameter 76 mm, max. reel diameter 400 mm - Platen sealing station with 4 guide rods for lifting table: - integrated overload safety system - automatic retracting of upper sealing plate at machine stop - Contact cooling station 357.202,30 Line-Quotation 500120809 Page 4 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ - Empty module for retrofitting of an additional station - Web indexing by 2 clamping grippers - Punch station with blister lowerator - Waste cutter with motorized indexing of scrap web - Monitoring of compressed air supply with machine stop, if air pressure falls below pre-set level - Machine guarding: - folding doors at operator side, made of scratch-proof easy-clean safety glass - plug-in doors made of acrylic glass at rear side - electro-mechanical interlocking of doors at operator side with door-open message on control panel indicating which door is open - Rapid format changeover: - all adjustable stations are set by digital indicators - no hand tools needed for format changeover - plug-in connectors for cooling water - Servo-driven main drive - Control cabinet at machine rear side - Pilot lamp tower, 4 colors with following standard occupation: - Red: Steady light: normal stop Flashing light: error, emergency stop - Orange: Steady light: material reserve control - Green: Steady light: machine is running Flashing light: automatic restart and start-up warning - Blue: Reserved for customer requests - Machine finish: Line-Quotation 500120809 Page 5 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ - painted machine parts and control cabinet: RAL 9007, grey aluminum TouchControl - HMI Operation - easy machine operation and adjustment of parameters by graphical user interface - access control through authorization system (user group and password) - fault display with integrated remedy recommendations - language selection Data Management - format data management - archive-, backup- and restore functions Logging - logging of production quantities and parameters - audit-trail as circular buffer Operation Terminal - 15" TFT screen - touch screen surface - 100BaseT-Fast Ethernet, TCP/IP protocol - USB interface for connection of printer, data back-up, etc. Industrial PC - Pentium M processor, min. 1.4 GHz - 1 GByte RAM, hard disk min. 30 GByte - uninterrupted power supply - Optional with external devices or interfacing with superordinate systems Integrated Shift Register prepared for connection to UHLMANN made fill control systems - recording of fill control signals - recording of production relevant errors, e.g. signals such as sealing overload, web splices, pinhole detection etc. Line-Quotation 500120809 Page 6 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ - programmable timers for each function for eject of single blister rows, i.e. overheated foil in the heating station, products in the sealing station, etc. - tracking of good and empty blisters and control of blister eject (partially filled blisters optionally) Machine control - Elau axis control with integrated soft SPS - CAN OPEN bus Technical data UPS 5 ET Number of cycles ET-section min./max. 15 / 50 cycles/min. depending on feeding system, format layout and quality of material Format range min./max. index in single stroke are 64/226 mm min./max. width of film 100/300 mm min./max. punching width 28/284 mm max. blister rows 8 max. forming depth 12 mm Power supply 400/230 volts ±10%, 3-phase, with loadable neutral conductor and separate protective earth conductor. Power supply network TN-S or TN-C-S (to be specified with order). Supply frequency 50 or 60 Hz (to be specified with order). Electrical equipment according to DIN EN 60204-1 resp. IEC 60204-1 Compressed air system pressure approx. 7 - 8 bar air consumption approx. 55Nm3/h Cooling water infeed temperature approx. 15 - 18°C volume approx. 1,1 m3/h Line-Quotation 500120809 Page 7 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ Documentation Operating Manual Scope of supply - 2 hardcopies in DIN A4 format - 1 CD-ROM in PDF format without interactive links to the contents of the operating manual Standard languages: English, German, French or Spanish. Standard languages of sub-supplier documentation: German or English; if available French or Spanish Contents - Introduction - Safety - Machine Data - Transport, Installation and Start-up - Layout and Features - Production mode - Machine Setup and Changeover - Malfunction - Maintenance - Touch Control Super User Manual - Error and remedy texts of operating system - Format Data Printout - Circuit and Fluid Flow Diagrams - Sub-Supplier Documents Spare Parts Catalogue Scope of supply - 2 hardcopies in DIN A4 format - 1 CD-ROM in PDF format without interactive links to the contents of the operating manual Available languages: German, English, French and Spanish Contents - Exploded view drawings of dynamic assembly groups helping to identify standard parts and components of the machine - Parts lists of dynamic assembly groups Line-Quotation 500120809 Page 8 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ Following items are not covered: - Format parts - Electrical parts and fluid parts - Sub-supplier equipment Note For technical reasons the spare parts catalogue can only be completed shortly before delivery of the machine. During FAT a sample catalogue will be available. __________________________________________________________________________________ 2000 1 EA 81010969 Components for working PP foils - only for ampoule blisters - 93.229,50 - reciprocating clamping gripper before heating station - forming station - forming station remains closed after machine stop - extended forming air - heated plug assist - additional cooling station after forming - cooled fill section - extended cooling station after sealing, incl. additional module Maximum 35 strokes/minute in the single stroke area, depending on film quality, feeding system and format layout, increased consumption of cooling water __________________________________________________________________________________ 2500 1 EA 81010971 Components for producing sealed ampoule-, syringe-, carpule blisters etc. - cooled fill section - increased forming depth up to 28 mm 38.620,40 Line-Quotation 500120809 Page 9 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ - plug assist for mechanical pre-forming - gripper index after forming with integrated shrinkage compensation - monitoring of waste web: in case of transport length variations machine is stopped in order to avoid broken glass in punch. Control via angular encoder. Remark: maximum machine speed with forming depth of 28 mm is 35 strokes/min. __________________________________________________________________________________ 3000 1 EA 81010973 Extension of forming depth from 28 to 40 mm 18.218,20 Maximum speed: 30 strokes/min. Blisters with a forming depth below 28 mm cannot be produced __________________________________________________________________________________ 3500 7 EA 81010974 4.406,56 30.845,90 Extension of basic machine by additional modules __________________________________________________________________________________ 3750 1 EA 0 81004971 2.138,50 Machine height increase of approx. 100 mm __________________________________________________________________________________ 4000 1 EA 81011455 Remote Maintenance using Broadband Internet Connection Standard package for the individual machine Software and hardware components for remote access to industrial computers to enable maintenance, supervision and updates of machine relevant software sections - online access to operational software TouchControl - access to intelligent machine devices e.g. camera systems, machine computers, etc. - a transfer rate of up to 100 MBit/s can be achieved (depending on the quality 2.502,50 Line-Quotation 500120809 Page 10 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ and distance of the internet-connection) - the customer to provide an internet-connection to the second network interface on the machine computer - firewall requirements to be agreed with customer - third party software licenses - configuration software to access an Internet line __________________________________________________________________________________ 4250 1 EA 81010990 Display texts, machine labels and operating manuals in Swedish language 6.533,80 This option does not include: - Circuit and Fluid Flow Diagrams - Sub-Supplier Documents These documents will be delivered in German or English. __________________________________________________________________________________ 5125 1 Parts Manager EA 81010992 Exploded view drawings on CD-ROM with interactive parts identification. By means of this interactive program, parts and assembly groups can be easily identified, displayed and printed out. Program features - graphic and text guidance through all group levels - various display selections of text and graphic pages - automatic generation of spare parts orders - searching and memorizing functions - selectable operator's languages (German, English, French, Spanish) - stored assistance texts - easy installation at local PC (set-up function Windows 98, NT, 2000, XP) The scope of the exploded view drawings is identical with the contents of the spare parts Line-Quotation 500120809 Page 11 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ catalogue. Note For technical reasons the Parts Manager can only be completed shortly before delivery of the machine. During FAT a sample Parts Manager will be available. - free of charge __________________________________________________________________________________ 6000 1 EA 81011021 3.075,80 Flow monitoring for cooling water, incl. machine stop and fault display on screen __________________________________________________________________________________ 6500 1 EA 81011022 Temperature monitoring of cooling water outfeed in combination with machine stop and display 2.102,10 __________________________________________________________________________________ 7000 1 EA 81011026 3.876,60 Splice detection for forming material, splice in- or outside, with disengaging of dedicated feeding systems and automatic eject of faulty strokes __________________________________________________________________________________ 8000 1 EA 81011029 3.876,60 Splice detection for lidding material, splice in- and outside, automatic eject of faulty strokes. Shut-off of dedicated feeding system only if technically possible. __________________________________________________________________________________ 8500 1 EA Wire numbering according to Uhlmann standard 81011034 10.637,90 Each wire receives at its end the connection number as per wiring diagram with closed, captive bushes __________________________________________________________________________________ 9000 1 EA 81011047 Near end forming material warning by buzzer and display on screen 4.195,10 Line-Quotation 500120809 Page 12 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ __________________________________________________________________________________ 9500 1 EA 81011051 Lid material reel support mounted on rear machine side, recommended for mounting a printer: 25.025,00 - 2-up lid material unwind - 2 pneumatical shaft spreaders for reel core diameter 76 mm, max. reel diameter 400 mm - reversing shoulder __________________________________________________________________________________ 10000 1 EA 81011052 Cutting and splicing table for lid foil 3.130,40 __________________________________________________________________________________ 10250 1 EA 81011053 4.195,10 Near end lid material warning by buzzer for lid material reel support __________________________________________________________________________________ 10500 1 EA 81011055 Lateral web control for lid material 12.703,60 for precise alignment of material reel, max. +/- 5 mm, automatic format setting via operating panel __________________________________________________________________________________ 11250 1 EA 0 81004991 Second inspection station on fill section for presence check of polybags - lighting box with incident LED-lighting and lift - one b/w camera with all necessary optics and cables 15.187,90 Note: Connected to VisioRead camera, pos. 16250 __________________________________________________________________________________ 11625 1 EA 0 81004991 Third inspection station for reading pharmacode on lid foil, comprising of - LED-lighting unit in application 7.498,40 Line-Quotation 500120809 Page 13 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ specific version - one b/w camera with all necessary optics and cables Required if reading of pharmacode needs to be realized at a different position than verifying the inline printed variable data. In this case, only two camera heads will be mounted to lighting box of VisioRead basic system (i.e. number of additional cameras as per Pos. 16438 of this quotation will be reduced to one). Note: Connected to VisioRead camera, pos. 16250 __________________________________________________________________________________ 12000 1 EA 81011092 10.856,30 Print registration by index correction __________________________________________________________________________________ 12500 1 EA 81011096 8.535,80 Index extension to 272 mm __________________________________________________________________________________ 13000 1 EA Chiller for ampoule trays etc. 81011183 19.337,50 - digital temperature display - refrigerating capacity 10,9 kW - min. supply temperature 8°C - cooling agent CFC-free - painting RAL 9007 - mains and water supply from blister machine __________________________________________________________________________________ 14000 1 EA 0 81004994 Thermotransfer printer for printing batch number and expire date on pre-printed lidding paper, including print layout configuration software. The printer must be able to print min. 5 rows with 20 digits in each row. Final design of the printer type can only be determined after clarification of the print. Max. print dimension with one print head is approx. 213mm x 100mm (213mm across travel direction, 100mm along travel direction). For any bigger print area, a second 81.090,10 Line-Quotation 500120809 Page 14 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ printer is requested. NOTE: Guarantee of function and performance only after examination of the original material to be printed. __________________________________________________________________________________ 14500 1 EA 0 81004995 Automatic Robot Feeding System incl. cassette belt conveyor 169.596,70 - automatic feeding system for Polybags via robotic system - feeding of 2 Polybags each cycle with machine speed of 20 cycles/min. - polybag infeed is 40 pieces/min. - polybags provided without any tags or labels for safe pick-up process - polybags provided via servodriven intermitted cassette belt conveyor, controlled by the UPS5 blister machine - length of conveyor approx. 2000 mm - pitch of the cassettes equal to the blister distance in the formed web- no gripper arm with spreading function necessary - the cassette belt conveyor is mounted from the rear side and in 90° angle to the travel direction of the blister machine - reject station for not picked polybags included, without bin for rejected products - a 100% filling of the cassettes by the customer is requested, if not, empty blisters can appear. The interface to the Uhlmann cassette belt conveyor is still not defined (manually or automatically) and is under responsibility of Astra Zeneca - fast clamping system of the format cassette belt __________________________________________________________________________________ 16250 1 EA 0 81004999 Print inspection system VisioRead Multifunctional camera inspection system for - among others - checking of imprints System description - 1-chip black/white CCD-camera with a resolution of up to 1.380 x 1.035 pixels - possibility to connect up to 8 cameras - touch panel for operation and representation of the inspection layouts and evaluations - TCP/IP interface for external format storing, internal format storing on flash disk and USB-stick VisioKey 41.969,20 Line-Quotation 500120809 Page 15 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ - interfaces for link to machine control - homogeneous illumination of the entire inspection area with incident light - shielding of external light - operator guiding for teach-in of formats - multi-trigger function for resolution increase - ample online diagnostic functions, e. g. line grey-scale values, measured values and error causes - evaluation of print presence, quality and position - evaluation of good and bad production in pieces and as percentage - individual character verification (OCV function) within a defined inspection area - code reading function for different kinds of codes - batch related statistic with error log - GMP compliant design - 21 CFR Part 11 compliant as per FDA Safety features - system self-control - data-valid-signal parallel to result outputs - wire-break proof signaling - 4 authorization levels, access via password Note Guarantee on function and performance after examination of original material with imprint __________________________________________________________________________________ 16375 1 EA 0 81004999 4.459,00 LED lighting instead of fluorescent lamps __________________________________________________________________________________ 16438 1 EA 0 81004999 Additional b/w camera, high resolution For a total of three camera heads within 5.696,60 Line-Quotation 500120809 Page 16 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ lighting box of VisioRead basic system one camera head (= 1 per blister lane) for OCR/OCV of imprinted variable data at one narrow end of blister one camera head for reading of pharmacode __________________________________________________________________________________ 16500 1 EA 81011146 Belt transfer for ampoule blisters without lid foil, with 1-lane linear blister outfeed 33.824,70 - outfeed belt below punch - jam control below the punch - intermediate belt with separation of good and faulty blisters by holding fingers - reject belt for single reject of faulty blisters, with reject cross-check - transfer belt, 1700 mm long, with separate drive - pneumatic blister separation - ejection of good blisters in case of cartoner stop with jam control __________________________________________________________________________________ 19000 1 EA Complete tool set 81014514 consisting of: - upper forming tool with plug assist with coating with direct cooling - lower forming tool with coating with direct cooling - set of guide tracks - upper sealing tool - lower sealing tool - punch tool 58.558,50 Line-Quotation 500120809 Page 17 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ for pos. 1a-1c __________________________________________________________________________________ 19500 1 EA 81014545 28.173,60 Format parts for robotic feeding system for pos. 1a-1c __________________________________________________________________________________ 20000 1 EA 81014547 7.389,20 Format parts for ampoule transfer system for pos. 1a-1c __________________________________________________________________________________ 20250 1 EA 81000000 gross price Discount (Value) of 46.610,00 15.000,00 46.610,00 30.126,48- Format parts for cassette belt conveyor for Pos. 1a-1c - 3 cassette belts, special designed for format a, b and c Note: Original price for cassette parts was EUR 46.610,Reduced price for AstraZeneca: 15.000,(9% corp. discount are considered) __________________________________________________________________________________ Option: 20500 1 Spare parts kit EA 81000000 30.858,10 __________________________________________________________________________________ Price ex works, excluding packing considered discounts total gross prices 9 % Corp. discount of Discount (Value) of Packing & Handling 1.129.282,80 1.240.970,11 46.610,00 1.271.096,59 111.687,3130.126,48- 7.750,00 Line-Quotation 500120809 Page 18 of 25 Date 07.07.2010 Insurance charges 2.310,00 Freight Charges 2.850,00 _____________ Total 1.142.192,80 ============= Line Quotation consisting of Page 19 of 25 Date 07.07.2010 500120809 ZA5 Uhlmann Blister Machine UPS 5 ET - Version: 2 500125101 ZA5 Validation and Services - Version: 1 Validation and Services __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ 1000 1 EA 81005503 Basic Scope for Qualification Documentation of the Blister Machine DOCUMENTS FOR DESIGN QUALIFICATION (DQ): - Qualification overview - List of abbreviations - Software Assurance Letter - Machine layout - Qualification of our employees - Uhlmann ISO 9001 Certificate - Risk Analysis machine - Risk Analysis Automation - Material Specification for product-contacting parts - Functional specification according to Uhlmann standard, comprising: - System description - General data - Product flow diagram - Description of assembly groups including indication of relevant electrical components - Hardware Design Specification Automation - Software Design Specification Automation DOCUMENTS FOR INSTALLATION QUALIFICATION (IQ): - PLC-programm printout on CD - Installation Qualification general - Installation Qualification sensors and actuators - Installation Qualification automation - Certificate PT100 Sensor - Calibration heating elements - Final report DOCUMENTS FOR OPERATION QUALIFICATION (OQ): - Operation Qualification machine - Operation Qualification automation - Final report 21.048,30 Line-Quotation 500125101 Page 20 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ Layout of qualification documentation The qualification documentation is available in German or English language, following international rules. Qualification documentation following customerspecific rules can be quoted as an option. Scope of supply of the qualification documents - 1 hardcopy in DIN A4 format - 1 CD-ROM in PDF format Delivery time As every individual sensor needs to be described in detail, the documentation can only be finished and supplied after completion of the FAT. The complete qualification documentation will be delivered with the machine. Further Qualification Services Upon request we can optionally quote further qualification services like: - diagrams such as block diagrams, product flow schemes with sensors and actors - sensor/actor plans - validation plan - loop test - traceability matrix - validation support by an Uhlmann engineer - preversions of documents etc. __________________________________________________________________________________ Option: 1360 1 EA Traceability Matrix 81009926 - for the first Uhlmann machine of the line - 21.603,40 Line-Quotation 500125101 Page 21 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ Separate document with cross references from URS items to Uhlmann documents such as Functional Specification, Hardware Design Specification, Software Design Specification, IQ and OQ Note: These documents will only be available in German or English language. __________________________________________________________________________________ 1469 1 EA 0 81005592 Qualification Documentation for robotic system 12.676,30 - Hardware Design Specification - Software Design Specification - Risk analysis - Installation Qualification sensors - Operation Qualification - Final report Note: These documents will only be available in German or English language. __________________________________________________________________________________ 2000 1 EA 81012431 Qualification documentation for VisioRead 1.920,10 - Risk Analysis (RA) - Installation Qualification (IQ) - Operation Qualification (OQ) Remark: The qualification documentation is made out in German or English language according to Uhlmann standard and printed out black and white on DIN A4 hardcopy, 1-up. __________________________________________________________________________________ 2500 1 EA 81011821 Installation and start-up of the machine on site by 1Uhlmann technician for the duration of 2 weeks. 18.209,10 Each further day will be invoiced separately at cost. __________________________________________________________________________________ 3000 1 EA 81011821 10.519,60 Line-Quotation 500125101 Page 22 of 25 Date 07.07.2010 __________________________________________________________________________________ Pos. Quantity Unit Article No. Price per unit Value in EUR __________________________________________________________________________________ SAT of the machine on site by 1Uhlmann technician for the duration of 1 week. Each further day will be invoiced separately at cost. __________________________________________________________________________________ Position total considered discounts total gross prices 9 % Corp. discount of 64.373,40 70.740,00 70.740,00 6.366,60- __________ Total 64.373,40 ========== Line-Quotation 500125101 COMMERCIAL CONDITIONS Prices CIP Södertälje (INCOTERMS 2000), including packing, excluding installation and commissioning. Shipment by truck Country of origin Germany Currency EURO Freight charges The freight charges indicated are based on standard packaging. The actual freight charges might be different and will be invoiced accordingly. FAT The prices quoted include 3 days of FAT at Uhlmann. Further days can be quoted as an option Delivery time Based on current manufacturing lead times approx. 9 months after receipt of order and clarification of all technical and commercial details. After receipt of order we will inform you about dates for availability of signed drawings, trial materials etc. Together with your order, a signed floor plan will be needed. Payment 30 % down payment after both parties have signed the local purchase order 30 % when the machine has successfully completed a FAT and delivered to AstraZeneca Umea 30 % after installation, commissioning, SAT and training of AstraZeneca's operator and maintenance personnel 10 % upon Take Over Certificate has been signed by the parties All payments are due: 30 days after receipt of invoice. according to Multi National Agreement No. 112117 Page 23 of 25 Date 07.07.2010 Line-Quotation 500125101 Page 24 of 25 Date 07.07.2010 Global Agreement Multi National Agreement will be taken into consideration for this project. Price validity The quoted prices are valid for 3 months, starting from date of quotation Note This offer is without engagement on our part until receipt of original products. This quotation is valid for budgetary purposes only. Please understand that the pricing may change after a detailed review of the technical and commercial requirements. Warranty period The warranty period is 12 months or 3000 operating hours, whatever comes first. The warranty period starts after installation, commissioning and takeover of equipment by purchaser, confirmed by a takeover protocol signed by both parties, however latest 3 months after shipment in case the delay of the takeover of the equipment is not due to any fault of Uhlmann. An extension of the warranty period can be quoted as an option. Machine installation at your site For installation and commissioning of the machines we recommend our service engineers. The cost will be charged against actuals. Material for trial runs An exact specification of the trial run material needed will be sent with the order confirmation. Please take into account that Uhlmann is not able to accept active products. The trial run material has to be put to our disposal without any cost for us. Used and unused test material will be disposed by Uhlmann. A disposal certificate can be quoted optionally. Upon request we can also return the material. The cost arising will be charged against actuals. Line-Quotation 500125101 Page 25 of 25 Date 07.07.2010 Intellectual property (1) To the extent that Uhlmann Pac-Systeme GmbH & Co. KG owns intellectual property rights, including patents, utility models, trademarks, copyright, design rights, know-how, trade secrets or other protective rights pertaining to the contractual performances (products or services), or acquires such rights in the course of executing the contract or licenses such rights from third parties for the purpose of providing the contractual performances, such intellectual property rights shall remain with Uhlmann Pac-Systeme GmbH & Co. KG or the third party licensor, and the customer shall acquire only the rights to use as contractually agreed. (2) Uhlmann Pac-Systeme GmbH & Co. KG assumes no liability for the protectability or the validity of the protective rights pertaining to the contractual performances. (3) Uhlmann Pac-Systeme GmbH & Co. KG affirms that it has no knowledge of other third party rights pertaining to the contractual performances, but assumes no responsibility that the contractual performances do not violate other third party protective rights. Uhlmann Pac-Systeme GmbH & Co. KG Sebastian Schubert Sales Support Engineer Günter Ziarnetzki Sales Support Manager Enclosure General Terms and Conditions 08/2006 Blister drawing Floor plan no. 11420165-01 This document is computer generated and valid without original signature. Page 1 of 1 Date 07.07.2010 Customer-Number: 4200002 AstraZeneca Sweden Operations Drug Products Supply Gärtuna Godsmottagningen Byggn 621 SE-151 85 SÖDERTÄLJE SCHWEDEN Price-Summary for project 999102144 Line Quotation consisting of Quotation No. EUR 500120809 Uhlmann Blister Machine UPS 5 ET - Version: 2 500125101 Validation and Services - Version: 1 1.142.192,80 64.373,40 _____________ Total 1.206.566,20 ============= Uhlmann Pac-Systeme GmbH & Co. KG Sebastian Schubert Sales Support Engineer Günter Ziarnetzki Sales Support Manager Enclosure General Terms and Conditions 08/2006 Blister drawing Floor plan no. 11420165-01 This document is computer generated and valid without original signature.