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User can also set various simulation parameters through the dialog box interface. The functions of various buttons on each sub-page are described below, including 5 parts: the main interface of the parameter setting, the medium interface, the light source interface, the detector interface and the interface of the simulation properties. 1. Main Interface of the Parameter Setting Click ‘Add spectrum,’ where users can add a new spectrum as shown in Figure 19. Due to the different optical parameters among different spectra, users should enter the optical parameters of the tissues and source parameters corresponding to the new spectrum. Figure 19 Dialog box of adding a new spectrum. Click ‘Del Spectrum,’ users can delete the selected spectrum shown as Figure 20. Click “OK,” and all of the optical parameters of the tissues and the source parameters corresponding to the spectrum will be deleted. Figure 20 Dialog box of deleting a spectrum. Click ‘Apply,’ and users will save all of the parameters in the interface. Click ‘Cancel,’ and users will quit the ‘Parameter Setting’ dialog box without saving the parameters. Click ‘OK,’ and users will save all of the parameters and quit the ‘Parameter Setting’ dialog box. 2. Medium Interface In MOSE, the simulation object is defined as medium, and it consists of a homogeneous medium (contains only one tissue) and heterogeneous medium (contains more than one tissue). Parameters used to define the tissue consist of the shape and optical parameters. The shape can be regular (2D: rectangle, ellipse; 3D: cube, ellipsoid, cylinder) or irregular (triangle mesh). The 18