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TABLE OF CONTENTS I. Introduction....................................................................................... 1 II. Abnormal Pressure........................................................................... 2 III. Leaks................................................................................................ 4 IV. Problems with the Chromatogram.................................................... 6 V. Problems with the Injector.............................................................. 14 VI. Problems Detected by Smell, Sight, or Sound............................... 15 VII. Key Problem Areas and Preventive Maintenance........................... 17 SecurityGuard Universal HPLC Guard Cartridge System.............. 19 Phenex Syringe Filters.................................................................... 20 © 2008 Phenomenex, Inc. All rights reserved. No part of this booklet may be copied without prior written permission from Phenomenex, Inc. USA. While every attempt has been made to ensure the accuracy of the information contained in this guide, Phenomenex assumes no responsibility for its use. We welcome any additions or corrections for incorporation into future editions.