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Acc U Rate® CMS 50F PLUS User Manual such as methylene blue, indigo green and acid indigo blue, carbon monoxide hemoglobin (COHb), methionine (Me+Hb), thiosalicylic hemoglobin or icterus, the SpO2 readings may be inaccurate. C. Drugs like dopamine, procaine, prilocaine, lidocaine and butacaine may also affect the accuracy of SpO2 measurement. D. Patients with serious anemia may also report good SpO2 measurement. 20