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width resolution. ImageDist * 0 The image distance of the detector. FocalLength * 0 The focus of the lens. LensRadius * 0 The radius of the lens. fiberdetector 7 The detector type and their numbers. Fiberdetectorshape cylinder The shape of the fiber detector. The current vision of MOSE Ellips- only supports cylinder and ellipsoid. The default shape is oid ellipsoid. FiberdetectorCenter 000 The center of the fiber detector. FiberdetectorAxis 000 The half of the axis length of the fiber detertor. endmse The keywords to end the parameter file. NOTE: 1. File header; 2. Simulation properties; 3. Spectrum list; 4. Light source parameters; 5. Medium parameters; 6. Detector parameters; 7. Detector parameters 3.2.2 Description of the Light Source, Medium Model, Detector and Region of Interest 3.2.2.1 Light Source In the latest version of MOSE, the types of light sources include three kinds shown in Table16. Table 16 can be a reference when user set the properties of the light source. Table 16 Differences in the light source properties from different simulation types Forward simulation type Properties BLT Luminescence type Shape Position DOT FMT Bioluminescence Incident laser Incident laser (Excitation), fluorophore (Emission) Not limited Not limited Not limited Inside the Inside or outside the medium medium The incident laser can be inside or outside of the medium. The fluorophore must be inside the medium. ‘Yes’ can be set while Specular reflectance No the incident laser is outside of the ‘Yes’ can be set while the incident laser is outside of the medium medium Solid/Face Not limited Not limited Not limited Including central Including central 1. Spectrum wavelength, wavelength, spectrum laser include central wavelength, spectrum parameters spectrum energy, energy, and photon energy, and photon number. and photon number 2. The spectrum parameters of the incident The spectrum parameters of the fluorophore 50