Download Exercise 1

WHO/TDR Bioinformatics Workshop at ICGEB, New Delhi (2005)
Module 3: Artemis Advanced
The region you should be looking at is shown below and is a classical example of
what is referred to as a Salmonella pathogenicity island (SPI). The definitions of what
actually constitutes a pathogenicity island are quite diverse. However, below is a list
of characteristics which are commonly seen within these regions, as described by
Hacker et al., 1997.
1. Often inserted alongside stable RNA’s
2. Atypical G+C contents.
3. Carry virulence-related functions
4. Often carry genes encoding transposase or integrase-like proteins
5. Unstable and self-mobilisable
6. Of limited phylogenetic distribution
Have a look in and around this region and look for some of these features.
Region 1 SPI-1
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