Download Cumate solution

SparQ™ Cumate Switch Inducible Expression System
Cat#s QMxxx
C. Mechanism of Transcriptional Control
The regulatory mechanisms of the bacterial operons cmt and cym have been engineered to regulate gene
expression in mammalian cells. In the repressor configuration, regulation is mediated by strong binding of the CymR
repressor to the Cumate operator site (CuO), which is downstream of the CMV5 promoter. Addition of cumate, a
small non-toxic molecule, relieves the repression.
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