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2 Introduction For the TProfessional Manager Software Biometra pursues the idea to provide a software that allows to control TProfessional thermocyclers in a powerful network. To achieve this goal an efficient control software has been developed and the concept for programming thermocyclers of the TProfessional line was integrated. The result is an easy to use software with intuitive operating interface as it is known from the TProfessional Thermocyclers themselves. 2.1 TProfessional Manager The Biometra TProfessional Manager is a PC-Software that allows to install and to control a network of up to 5 Thermocyclers of the TProfessional series. With the Manager Software programs can be created, edited or saved and user directories and programs can be exchanged between the PC and the TProfessional Thermocyclers. The handling of the TProfessional Manager is based on the intuitive user interface of the Thermocyclers with the choice for tabular or graphical programming. For documentation of PCR runs detailed log-files with temperature data can be saved. If problems occur, in an extended self test Service Info Files are created that can be analysed by Biometra`s Service for rapid failure diagnosis. User manual TProfessional Manager Software January 2009 5