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GeneSight Users Manual
The procedure strings out the spots according to brightness, then normalizes each
spot by looking at a neighborhood of nearby spots, and normalizing the group.
The parameters to be documented are:
Smoothing parameter: The level of influence of a spot's neighbors on its
normalization adjustment. Higher values mean that the normalization is more
continuous across spots.
Linear/quadratic: The assumed shape of the curve relating interchannel bias to spot
brightness. Quadratic provides more flexibility, linear is faster.
Normalization Scope: You can group all spots together ("Global" choice) or separate
spots into groups by their meta-grid ("Print-tip", see below).
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