Download Here - Diabetes Trials Unit

Number of bootstraps .............................................................................................................. 21 Start at bootstrap ...................................................................................................................... 22 Number of years simulated ................................................................................................... 22 Number of processes ............................................................................................................... 22 Discount rates ........................................................................................................................... 22 Therapy costs ............................................................................................................................. 22 Use these costs/utilities until age ........................................................................................ 22 Initial Utility value ................................................................................................................... 23 Cost in absence of complications ........................................................................................ 23 Utility Decrements ................................................................................................................... 23 Complication costs ................................................................................................................... 23 Currency Conversion Value ................................................................................................. 24 Reset Costs button .................................................................................................................... 24 Reset Utilities button ............................................................................................................... 24 Populate annual risk factor worksheet button ................................................................ 24 Verify Model Data button ...................................................................................................... 24 Inputs Check Worksheet (Figure 13) ...................................................................................... 24 Errors ................................................................................................................................................. 26 The Output Workbook ..................................................................................................................... 26 Outputs Worksheet ....................................................................................................................... 26 Bootstraps Worksheet .................................................................................................................. 28 Event Worksheets ......................................................................................................................... 29 KMPlotSheet Worksheet ............................................................................................................ 30 KM Plot Worksheets .................................................................................................................... 31 Worked Examples .............................................................................................................................. 32 EXAMPLE #1 ................................................................................................................................. 32 Step 1: Enter patient characteristics ................................................................................... 32 Step 2: Risk factor time paths .............................................................................................. 33 Step 3: Set up simulation ....................................................................................................... 33 Step 4: Run the simulation .................................................................................................... 33 EXAMPLE #2 ................................................................................................................................. 34 Step 1: Enter patient characteristics ................................................................................... 34 Step 2: HbA1c time path ........................................................................................................ 34 Step 3: Run model .................................................................................................................... 34 EXAMPLE #3 ................................................................................................................................. 35 Step 1 ............................................................................................................................................ 35 Appendix 1 : Enabling VBA macros in Microsoft Excel .................................................... 36 ii