Download User`s Guide: Chromeleon Operational

Dionex IC System OQ/PQ User’s Guide
1.1 How to use this manual
1.
Determine which tests are required for the system to be qualified and write them down on a
sheet of paper. This will help keep track of what steps to follow during system setup and
preparation. It will also aid in selecting the appropriate sequences to run the tests.
2.
For the DX500, DX600, and ICS2500 systems, electrochemistry cells are not used for any
qualification tests apart from noise and drift qualification. If a customer uses amperometry
methods, a conductivity cell must be used in its place to perform injector and gradient pump
tests.
3.
For the ICS-3000 system, electrochemistry cells in Integrated Amperometry mode are
supported for qualification tests. If using Integrated Amperometry detection, a conductivity
detector must be used in its place to perform a gradient pump test (pump flow test and EG test
should also be run in conductivity mode). For a system with only electrochemical detectors, it is
suggested that a complete system qualification be performed with a conductivity detector
(including pump gradient accuracy, flow rate, and EG), after the system has been qualified with
the conductivity detector, the detector should be exchanged for an ED detector. The ED tests
(noise and drift, detector linearity) can be executed as described in this manual. The ICS-3000
electrochemistry detector DC amperometry and cyclic voltametry modes are not supported.
When qualifying Integrated Amperometry detection a disposable gold working electrode is use.
Other electrodes are not supported.
4.
Use the Table of Contents and the List of Tables as reference guides to locate information
quickly.
1.2 List of Tables
•
Chromeleon 6 minimum version requirements .....................................................................6
•
Overview of the tests.....................................................................................................8 – 12
•
Materials in kit. ....................................................................................................................17
•
Additional Required Materials. ............................................................................................19
•
Preparation of eluents for use with Conductivity Detection.................................................20
•
Preparation of eluents for use with Absorbance Detection .................................................21
•
AS50 Standard order...........................................................................................................21
•
AS40 / Manual Injection Standard order .............................................................................22
•
Instrument and Channel names ..........................................................................................24
•
IC System Checks.......................................................................................................26 – 27
•
OQ/PQ Test Timetable........................................................................................................39
•
Failure of individual tests.....................................................................................................56
1.3 Operational Qualification (OQ)
According to “The Development and application of guidance on equipment qualification of analytical
instruments” by P. Bedson and M. Sargent [Accred. Qual. Assur. (1996) 1: 265 – 274] the following
definition applies:
031726-15 OQ PQ Operating Instructions rev 5.11.doc
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