Download Chapter 1 - Worcester Polytechnic Institute

Table of Contents
Table of Contents .......................................................................................................................................... 1
Authorship .................................................................................................................................................... 4
Acknowledgements....................................................................................................................................... 5
Abstract ......................................................................................................................................................... 6
Table of Tables .............................................................................................................................................. 7
Table of Figures ............................................................................................................................................. 8
Chapter 1 – Introduction............................................................................................................................. 10
Chapter 2 – Literature Review .................................................................................................................... 14
2.1 Mechanical Conditioning .................................................................................................................. 14
2.1.1 Definition ................................................................................................................................... 14
2.1.2 Impact on TEBV Structure and Properties ................................................................................. 15
2.1.3 Types and Studies Demonstrating Mechanical Conditioning Techniques ................................. 18
2.1.4 Conclusions ................................................................................................................................ 21
2.2 Bioreactors ........................................................................................................................................ 22
2.2.1. Current bioreactor designs ........................................................................................................... 23
2.2.2. Areas for improvement and design opportunities ....................................................................... 26
Chapter 3 – Project Strategy ....................................................................................................................... 28
3.1 Initial Client Statement ..................................................................................................................... 28
3.2 Objectives.......................................................................................................................................... 28
3.3 Constraints ........................................................................................................................................ 30
3.4 Revised Client Statement .................................................................................................................. 31
Chapter 4 – Alternative Designs.................................................................................................................. 32
4.1 Functions (Specifications) ................................................................................................................. 33
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