Download MSQ Installation and Commissioning Guide

______________________________________________________________________________ Contents
Positive Ion APCI Sensitivity ...................................................................................2-21
Negative Ion APCI Sensitivity..................................................................................2-22
Negative Ion ESI Sensitivity.....................................................................................2-23
Preparation for Sensitivity Tests......................................................................................2-24
Setting up an Xcalibur Acquisition ...........................................................................2-24
Introduction...............................................................................................................2-24
General Method.........................................................................................................2-25
Surveyor MSQ Signal-to-Noise Calculator ..............................................................2-26
Acquisition of Specification Chromatograms..................................................................2-27
Positive ESI...............................................................................................................2-27
Positive APCI............................................................................................................2-30
Negative APCI ..........................................................................................................2-31
Negative APCI ..........................................................................................................2-32
Negative ESI .............................................................................................................2-34
Instrument Acceptance .................................................................................................................2-36
Sign-off Liability.......................................................................................................2-36
Those tasks which must be completed before Sign-off ............................................2-36
Those tasks that must not be performed before Sign-off ..........................................2-36
Additional Options........................................................................................................................2-37
Surveyor MSQ Connection Kits ...............................................................................2-37
LapLink™ .................................................................................................................2-38
Connecting the MSQ to the HPLC System ..................................................................................2-39
Supported Systems ....................................................................................................2-39
Unsupported Systems................................................................................................2-40
Timing.......................................................................................................................2-40
Completing the Installation...........................................................................................................2-41
Appendices.................................................................................................................................3-1
Appendix A: Sample Preparation ...................................................................................................3-2
Introduction.................................................................................................................3-2
Supplied Samples........................................................................................................3-2
Required Samples .......................................................................................................3-2
Suggested Method for Sample Preparation.................................................................3-3
Sample Preparation .....................................................................................................3-3
Erythromycin 5pg/µL .................................................................................................3-3
50:50 Acetonitrile:Water ............................................................................................3-4
Hazard Information.....................................................................................................3-5
p-Nitrophenol 2pg/µL.................................................................................................3-5
Appendix B: Surveyor MSQ Signal-to-Noise Calculator...............................................................3-7
Tutorial ..............................................................................................................................3-7
Toolbar...............................................................................................................................3-8
_____________________ Installation and Commissioning Guide _________________________ iii