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cd-hit-2d -i db1 -i2 db2 -o db2new -c 0.9 -n 5 cd-hit-2d -i db1 -i2 db3 -o db3new -c 0.9 -n 5 clstr_merge.pl db2new.clstr db3new.clstr > db23new.clstr clstr_ renumber.pl It renumbers clusters and sequences within clusters in .clstr file after merge or other operations Commands: Clstr_renumber.pl input.clstr > input_ren.clstr clstr_rev.pl It combines a .clstr file with its parent .clstr file