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7 Optimizing Your Method Adjusting the Transfer Line Temperature Adjusting the Transfer Line Temperature If your transfer line temperature is set too low, the less volatile compounds may get stuck in the transfer line and never make it into the ion source. On the other hand, if your transfer line is too hot, you could damage the column or cause a thermal breakdown in the compounds you are analyzing. Typically, the transfer line temperature should be 10 °C over the highest boiling point of the compounds of interest, but no more than the maximum safe operating temperature of the column. Increase the source temperature as well to improve response for high-boiling compounds and prevent column bleed and matrix compounds from dirtying the ion source. Note The transfer line temperature and ion source temperature should be similar to avoid contaminating the ion source. Thermo Scientific ISQ User Guide 91
