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Introduction to BiblioSphere PathwayEdition BiblioSphere PathwayEdition (BSPE) is a next-generation software system for dynamic, data driven retrieval and analysis of gene relation networks. BSPE is the only system available which combines literature analysis with proprietary genome annotation and promoter analysis. Relations between biological entities are based on independent information sources (multiple lines of evidence) which provides insights beyond current literature knowledge. BSPE is the only application where the user starts his analysis on base of the entire network of input genes, correlated genes and their biological connections. Various tools facilitate focusing on the most relevant biological context. BSPE is based on a client-server architecture which includes the BiblioSphere PathwayEdition Knowledge Database (BSPEKD) on the server side and a retrieval, visualization and analysis system for Network Generation and Analysis which is installed as a stand alone tool on the user’s computer (client side). © 2007 Genomatix Software GmbH 4 Introduction to BiblioSphere PathwayEdition